Monday, March 9, 2009

Stress in childhood may lead to inflammatory diseases later in life

Is there a chance that you might have had a stressful childhood before developing Behcet's? It happened to me, and who knows...maybe it happened to you, too.

Here are some abstracts and articles that can give you some more information. Two of the articles are available online for free.

1: Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB.
Cumulative childhood stress and autoimmune diseases in adults.
Psychosom Med. 2009 Feb;71(2):243-50. Epub 2009 Feb 2.
Excerpt: "Childhood traumatic stress increased the likelihood ofhospitalization with a diagnosed autoimmune disease decades into adulthood. Thesefindings are consistent with recent biological studies on the impact of earlylife stress on subsequent inflammatory responses."
PMID: 19188532

2: Jessop DS.
The fragile mind: early life stress and inflammatory disease.
Endocrinology. 2008 Jun;149(6):2724-6. No abstract available (sorry -- maybe your doctor can get a copy of this article. It may also be available at a local medical library)
PMID: 18493026

3: Danese A, Pariante CM, Caspi A, Taylor A, Poulton R.
Childhood maltreatment predicts adult inflammation in a life-course study.
Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1319-24. Epub 2007 Jan 17.
Full article available online for free, at:
PMID: 17229839

4: Pace TW, Mletzko TC, Alagbe O, Musselman DL, Nemeroff CB, Miller AH, Heim CM.
Increased stress-induced inflammatory responses in male patients with major
depression and increased early life stress.
Am J Psychiatry. 2006 Sep;163(9):1630-3.
Full article available online for free, at:
PMID: 16946190

1 comment:

  1. Thanks, Joanne, for the great work you do and this recent information. Terrific that most of the articles are free, too. Hope you are well.