Wednesday, May 19, 2010

Behcet's and your gums and teeth

I'm often asked whether people with Behcet's have an unusual amount of dental problems. Some people complain of having cavities along the gum line, while others have teeth that seem to fall apart or require a lot of crowns. And a small number of people give up entirely and have all of their teeth pulled, so that they can have dentures instead (which can lead to a whole host of other problems, like gum ulcers/lesions -- especially if the dentures don't fit well).

Face it, it can be hard to pay attention to your teeth and gums if you have a lot of problems with oral ulcers: Ulcers on your gums, tongue, and anywhere else in your mouth can make it really painful to brush and/or floss. Going to the dentist or periodontist can be a big problem, too, if you're one of the people who gets a flare following any dental work or cleaning.

While I was at the latest American Behcet's Disease Association medical conference at the end of April, a dentist spoke about BD and oral issues. He has a particular interest in the subject because his wife has Behcet's, and has needed an unbelievable number of root canals. Informal surveys that he's performed (including one that he did during his ABDA presentation) has shown that approx. 30% of BD patients have this need for multiple root canal procedures. If any readers have had this issue (or other tooth/cavity-related issues), please feel free to leave a comment at the end of this post. I'll forward relevant comments to the dentist, who is hoping to start formal research on this topic.

In the meantime, here are some summaries of published articles on Behcet's and dental problems:

The close association between dental and periodontal treatments 
and oral ulcer course in Behcet's disease: a prospective clinical study.
J Oral Pathol Med. 2009 May;38(5):410-5. Epub 2009 Mar 5.
Karacayli U, Mumcu G, Simsek I, Pay S, Kose O, Erdem H, Direskeneli H, 
Gunaydin Y, Dinc A.
Department of Oral and Maxillofacial Surgery, Gulhane School of Medicine, 
Ankara, Turkey. ukaracayli@gmail.com 
The aim of the study was to see the effect of dental and periodontal treatments 
on the course of oral ulcers in patients with Behcet's disease (BD). Fifty-eight 
BD patients with oral ulcers were studied. Twenty-nine patients were given 
dental and periodontal cleanings and treatment, while 29 in a control group 
were only given oral hygiene education. 
Results: There was an increase in the number of new oral ulcers within 
2 days of the treatment [period]. However, 6 months after the dental and 
periodontal treatments, the number of oral ulcers was significantly lower 
in the treated group compared with  the control group. 
Conclusion: The results suggest that, in BD patients, dental and 
periodontal therapies could be associated with a flare-up of oral ulcers 
in the short term, but may decrease their number in longer follow-up. 
They also lead to better oral health. 
PMID: 19320802 
 
Relationship between periodontal parameters and Behcet's 
disease and evaluation of different treatments for oral recurrent 
aphthous stomatitis.
J Periodontal Res. 2009 Dec;44(6):718-25. Epub 2008 Dec 11.
Arabaci T, Kara C, Ciçek Y. 
Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum, 
Turkey. t-arabaci@hotmail.com

"Since oral aphthous ulcers impair tooth brushing, reducing complaints about 
aphthous ulcers will motivate the patient to maintain better oral hygiene 
performance and will thus reduce plaque accumulation and periodontal scores. 
The purpose of this controlled case study was to evaluate the relationship 
between the severity of periodontal scores and Behcet's disease, and to 
compare the treatment modalities with neodymium-doped yttrium aluminium 
garnet (Nd:YAG) laser and medication on the recurrent aphthous ulcers in 
BD patients by considering the degree of pre- and post-treatment pain, 
discomfort and functional complications. 
Results: BD patients treated with the Nd:YAG laser had less post-treatment 
pain and fewer complications and reported immediate relief of pain and 
faster healing. 
Conclusion: Our results suggest that periodontal status is worse in 
BD patients and is associated with disease severity; also, the Nd:YAG 
laser has better patient acceptance, shorter treatment time and lower 
rates of pain and post-treatment adverse events among BD patients 
with oral recurrent aphthous stomatitis."
PMID: 19076988 [PubMed - indexed for MEDLINE]


Relationship between periodontal findings and the TNF-alpha Gene 
1031T/C polymorphism in Turkish patients with Behcet's disease
J Eur Acad Dermatol Venereol. 2008 Aug;22(8):950-7. Epub 2008 Mar 19. 
Akman A, Sallakci N, Kacaroglu H, Tosun O, Yavuzer U, Alpsoy E, Yegin O.
Department of Dermatology and Venerology, Akdeniz University School of 
Medicine,  Antalya, Turkey.

Background: "Genetic factors predispose individuals to Behcet's 
disease (BD)  and periodontal disease. Tumour necrosis factor-alpha 
(TNF-alpha) has been implicated in the pathogenesis [development] of 
both BD and periodontal disease. The relationship with periodontitis 
and the pathogenesis of BD has not yet been determined. 
Methods: Eighty-two unrelated patients with BD, 42 RAS [recurrent 
aphthous stomatitis] patients and 77 HC [healthy controls] were enrolled 
in the study. Periodontal status of all subjects was evaluated according 
to the World Health Organization community periodontal index of treatment 
needs (CPITN). 
Conclusions: Our data indicate that the TNF-alpha-1031T/C gene 
polymorphism (CC genotype) is a risk factor for periodontitis, RAS and 
BD patients and also suggests that long-term periodontal follow-up and 
education of oral hygiene in patients with BD may help to prevent the 
development and/or progression of the disease."
PMID: 18355201 

Relationship between periodontal findings and Behcet's disease: 
a controlled study.
J Clin Periodontol. 2007 Jun;34(6):485-91. Epub 2007 Apr 23. 
Akman A, Kacaroglu H, Donmez L, Bacanli A, Alpsoy E. 
Department of Dermatology and Venerology, Akdeniz University School 
of Medicine, Antalya, Turkey. aakman@akdeniz.edu.tr 

BACKGROUND: "Behcet's disease (BD) is a chronic, relapsing, systemic vasculitis of
unknown aetiology. The involvement of oral mucosal surfaces represents the onset 
feature of the disease in the majority of patients. 
OBJECTIVE: The aim of this study was to evaluate the periodontal status of BD patients 
and then compare with recurrent aphthous stomatitis (RAS) patients and healthy controls. 
We also determined the relationship between the periodontal condition and the clinical
severity of the disease in BD patients. 
METHODS: Eighty-six patients with BD, 63 patients with RAS and 82 healthy subjects 
were included in the study. The periodontal status of all subjects was evaluated
according to the community periodontal index of treatment needs (CPITN). BD 
patients were also assessed for  clinical severity score (CSS) as described previously. 
RESULTS: The mean CPITN
were observed to be higher in BD patients (1.79 +/- 0.96) compared with RAS
patients (1.22 +/- 0.87) and healthy controls (1.18 +/- 0.98) (p<0.001). There
was a positive association between CSS and CPITN (p=0.017) in BD patients.
CONCLUSION: Our results showed that periodondal status is worse in BD patients
and associated with disease severity. We can speculate that periodontitis may
induce a systemic inflammatory process that may contribute to the development
and/or progression of BD. "
PMID: 17451414 


Periodontal findings and systemic antibody responses to oral microorganisms in
Behcet's disease.
J Periodontol. 1999 Dec;70(12):1449-56. 
Celenligil-Nazliel H, Kansu E, Ebersole JL. 
Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara,
Turkey. 

BACKGROUND: "Behcet's disease is a multisystem disorder of unknown etiology,
affecting predominantly the oral mucosa, skin, and eyes. Recurrent and painful
episodes of oral ulcerations interfere with regular oral hygiene leading to rapid
bacterial plaque accumulation. The aims of this study were to evaluate the
periodontal status of patients with Behcet's disease and determine serum antibody
responses to selected oral microorganisms, including major periodontopathogens in
these patients. 
METHODS: Thirty-three patients with Behcet's disease and 15
healthy subjects were included in the study. Plaque, sulcular bleeding,
periodontal index scores, probing depths, and total number of teeth were
recorded. Serum IgG antibody levels to a panel of 13 oral microorganisms were
determined. 
RESULTS: Significantly higher values for each of the clinical
measures were observed in patients with Behcet's disease compared to healthy
subjects (P <0.0001). Antibody levels to selected members of plaque, including
Actinomyces viscosus, Streptococcus mutans, Streptococcus sanguis, Streptococcus 
oralis, Eikenella corrodens, Campylobacter rectus, and Prevotella intermedia were
significantly lower in patients with Behcet's disease than in controls (P
<0.001-0.05). In contrast, these patients exhibited significantly elevated
antibody levels to Actinobacillus actinomycetemcomitans Y4 compared to controls
(P <0.01). 
CONCLUSIONS: Our data indicate that the patients with Behcet's disease
generally exhibit clinical findings of established periodontal disease. Decreased
antibody responses to early colonizers of both supra- and subgingival plaque were
observed along with the elevation in antibody levels to A. actinomycetemcomitans.
These results suggest that the bacterial plaque ecology and/or immune responses
to these microorganisms may be affected in Behcet's disease which could lead to
changes in the expression of periodontal disease. "
PMID: 10632520 




9 comments:

  1. Rebecca MilliganMay 21, 2010 at 6:19 PM

    I have had terrible dental problems for many years. I have suffered from inflammed and bleeding gums,multiple root canals and periodontal disease.I also tend to flare after invasive dental procedures with multiple oral ulcers.

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  2. only 2 teeth that have caps on them flare up around the floor of the tooth, however it just began around 3 mths. ago. i had a really bad flu and sinus condition as well as bronchitis and repeated this illness again about a mth. ago. what should i do. i hate the discomfort. thank you. anfossio@hotmail.com

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  3. I have Behcets and had to have a root canal because my tooth hemorrhaged after a routine filling. I thought that was dentist error, but I just got another very small, shallow, minor filling and it's KILLING me. The dentist said there is nothing visibly wrong with the tooth, but if the pain doesn't go away, I might have to have another root canal. Say it ain't so! I can't afford this! The injection site where he gave me novacaine still hurts a lot 3 weeks later. My dentist had no idea about how Behcet's might have caused this pain. He said just wait and see if the tooth calms down. Is that possible, or is the tooth doomed? How can this reaction be avoided? It's miserable.

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  4. Joanne,
    As always you are a great advocate for those with Behcet's.
    To those that have commented here, I am a dentist with experience with Behcet's. Feel free to email me at davidindraper@yahoo.com If I can be of help, I would be glad to respond. If I don't respond immediately, be patient, I will within a week.

    David Petersen DDS

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  5. I have Behcets. Everytime my IgG gets low (for me) or after I've had a virus - my teeth/gums start to go bad. I've had gum surgery. I usually have root canals in groups of 2s or 3s. Now in my 40's my gums are receding and I'm having to re-do crowns and root canals because the bacteria gets around the crown or into the gums. The ulcers show up inside the gums pushing the teeth around. Behcets patients should always take antibiotics for a few days prior to tooth cleaning or treatments. Get regular cleanings & x-rays. Sensitive toothpastes help calm the teeth, as do moisturizing mouthwashes. Floss after foods that get caught. If you can handle the pain or do mild painkillers with an antibiotic course, SOMETIMES it will will calm the tooth/infection and you can escape a root canal.

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    Replies
    1. Wow..I have the same scenario with the virus.virus is connected to bechets? Everytime I get sinusitis I get the mouth sores after?? And it affects gums...I never noticed all these connecting dots before...I definitely have this...great!@ john

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  6. My BD symptoms began with mouth ulcers about 15 years ago. I had at least 2/3 flares a month for 4 years. About 3 years into this experience I developed gum disease (which I had never had before) had infections and gum surgery . My teeth had always been fairly healthy and very straight. But after a while they became loose and crooked with large gaps in my front teeth. The infections and gum disease finally got so bad that my dentist recommended I have all of them pulled. He gave me the option of implants or dentures. I choose dentures because the cost of implants was enormous. But I have a hard time wearing the dentures because they irritate my mouth and gums and seems to trigger mouth ulcers when I wear them for long periods of time. Now I only wear them when I go out, and that seems to keep down the ulcers. I've always wondered if the amount of mouth ulcers I experienced in the first 4 years caused me to lose my teeth.

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  7. My story is identical to yours. 15 years ago I started having mouth ulcers at least twice a month for four straight years. My teeth had always been excellent, no gum disease and very straight. Over time my teeth became loose and crooked with the large gaps in front, and for the first time in my life I developed gum disease.

    I went to the dentist regularly and was told I wasn't taking care of my teeth. Not true! I was always fastidious about my teeth. I had done extensive research on Behcet's as I had so many other symptoms and I tired to explain to the dentist(s) that I believed the Behcer's ulcers were causing the problems with my teeth. But he, like all my other docs had never heard of Behcet's. I was pretty much dismissed because I couldn't afford all the expensive treatments. Finally I had to have all my teeth extracted and opt for dentures because of the cost. I wear the dentures, but like you, I only wear them when I go out. It's a nightmare.

    In all these 15 years I've pretty much had to be my own doctor, submitting the latest findings and information on Behcet's to my doctors - even my Rheumy!

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