Sunday, January 25, 2009

Sixteen articles and abstracts about intestinal Behcet's

It can be hard to distinguish between the GI complications of Behcet's disease and problems that may be due to ulcerative colitis, Crohn's disease, celiac disease, or irritable bowel syndrome. Here are some articles and letters that you may want to share with your doctors. I've included links to free PDFs for eight of the articles; the remaining references are linked to their abstracts (your doctors will be able to get the full articles).

1) Endoscopy. 2009 Jan;41(1):9-16. Epub 2009 Jan 21.
Differential diagnosis of intestinal Behçet's disease and Crohn's disease by colonoscopic findings.
Lee SK, Kim BK, Kim TI, Kim WH.
Excerpt: "It was determined that round and longitudinal ulcers are suggestive of Behçet's disease and Crohn's disease, respectively. Irregular/geographic-shaped ulcers and focal distributions are suggestive of Behçet's disease, while segmental/diffuse lesions suggest Crohn's."
PMID: 19160153

2) J Gastrointestin Liver Dis. 2008 Dec;17(4):481-3.
Concomitant colitis in a patient with Behcet's disease.
Full article for free at: (Scroll to page 3)
Yilmaz Y, Dolar E.
Department of Internal Medicine, Uludag University School of Medicine, Uludag University Hospital, Bursa, Turkey.
Publication Types: Letter
PMID: 19104718

3) Am J Gastroenterol. 2008 Dec;103(12):3213-4.
Mycophenolate sodium: effective treatment for therapy-refractory intestinal Behçet's disease, evaluated with enteroscopy
Full article for free at: (Scroll to page 9)
Kappen JH, Mensink PB, Lesterhuis W, Lachman S, van Daele PL, van Hagen PM, van Laar JA.
Publication Types: Case Reports, Letter
PMID: 19086980

4) World J Gastroenterol. 2008 Dec 21;14(47):7271.
Differentiation of Behcet's disease from inflammatory bowel diseases: Anti-saccharomyces cerevisiae antibody and anti-neutrophilic cytoplasmic antibody.
Filik L, Biyikoglu I.
Gastroenterology Division, Ankara Research Hospital, Ziya Gokalp Cad. Isik Apt.72-14 Kizilay, Ankara 06600,
PMID: 19084948

5) World J Gastroenterol. 2008 Nov 14;14(42):6578-80.
Colonic perforation in Behcet's syndrome.
Full article for free at:
Dowling CM, Hill AD, Malone C, Sheehan JJ, Tormey S, Sheahan K, McDermott E, O'Higgins NJ.
Department of Surgery, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland.
PMID: 19030217

6) Clin Exp Rheumatol. 2008 Jul-Aug;26(4 Suppl 50):S91-5.
Frequency of pathergy phenomenon and other features of Behçet's syndrome among patients with inflammatory bowel disease.
Hatemi I, Hatemi G, Celik AF, Melikoglu M, Arzuhal N, Mat C, Ozyazgan Y, Yazici H.
Division of Gastroenterology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
Excerpt: "Despite similarities between the clinical features of CD [Crohn's disease] and UC [ulcerative colitis] with BS [Behcet's syndrome], coexistence is uncommon. ISG [Behcet's International Study Group] criteria perform well in differentiating these diseases. About 8% of IBD [inflammatory bowel disease] patients show the pathergy phenomenon."
PMID: 19026122

7) Dig Dis Sci. 2008 Nov 7. [Epub ahead of print]
Prevalence of Celiac Disease Among Patients with Behcet's Disease in Iran.
Zamani F, Shahram F, Shakeri R, Zayyeni H, Davatchi F, Amiri A, Malekzadeh R.
Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran.
PMID: 18989774

8) Rheumatol Int. 2008 Sep 26. [Epub ahead of print]
Behçet's disease: clinical value of the video capsule endoscopy for small intestine examination.
Neves FS, Fylyk SN, Lage LV, Ishioka S, Goldenstein-Schainberg C, Sakai P, Gonçalves CR.
Rheumatology Unit, University of São Paulo, Av. Dr. Arnaldo 455, 3 andar, sala 3133, Pacaembu, São Paulo, SP, CEP 01246-903, Brazil,
PMID: 18818923

9) Ann Rheum Dis. 2002 May;61(5): 459-62.
Humoral and cell mediated immune response to cow's milk proteins in Behcet's disease.
Full article for free at:
Triolo G, Accardo-Palumbo A, Dieli F, Ciccia F, Ferrante A, Giardina E, Licata G.

10) AJR Am J Roentgenol. 1994 Feb;162(2):349-50
CT evaluation of the gastrointestinal tract in a patient with Behcet's syndrome.
Full article for free at:
Johnson WK, Beierle E, Ros PR
PMID: 8310925

11) Abdom Imaging. 2001 May-Jun;26(3):309-14.
Intestinal Behcet's disease: breath-hold MR imaging.
You JK, Kim MJ, Park S, Chung JJ, Kim WH
PMID: 11429961

12) Radiographics. 2001 Jul-Aug;21(4):911-24; discussion 924-6
(This is one of my most-recommended articles -- good pictures)
Radiologic findings of Behcet syndrome involving the gastrointestinal tract.
Full article for free at:
Chung SY, Ha HK, Kim JH, Kim KW, Cho N et al.
PMID: 11452065

13) Inflamm Bowel Dis. 2008 Mar;14(3):396-400.
Thalidomide for treatment of intestinal involvement of juvenile-onset Behcet disease.
Yasui K, Uchida N, Akazawa Y, et al.
PMID: 17973303

14) Eur J Pediatr. 2005 Aug;164(8):523-5. Epub 2005 Apr 23.
Intestinal Behcet disease presenting as neonatal onset chronic diarrhea in an 11-month-old male baby. (No abstract available)
PMID: 15856294

15) Blood. 2004 Jan 15;103(2):748-50
Autologous hematopoietic stem cell transplantation for severe/refractory intestinal Behcet disease.
Full article for free at:
Rossi G, Moretta A, Locatelli F. PMID: 14702292

16) Radiology. 1998 Nov;209(2): 449-54.
Intestinal Behcet syndrome: CT features of patients with and patients without complications.
Full article for free at:
Ha HK, Lee HJ, Yang SK et al.
PMID: 9807572MID: 8310925